| Abstract | .... 2 | |
| 1 | Introduction | .... 3 |
| 1.1 | Review of Multiple Alignment | .... 3 |
| 1.2 | Need for Multiple alignment system with Refiner | .... 3 |
| 2 | Why is an intelligent refiner necessary? | .... 4 |
| 2.1 | Biological reliability of computationally optimal alignment | .... 4 |
| 2.2 | Possibility of Inference of biologically optimal alignment from computationally optimal Alignment | .... 5 |
| 3 | Multiple alignment system with intelligent Refiner | .... 6 |
| 3.1 | Framewaok of the Multiple alignment system with intelligent Refiner | .... 6 |
| 3.2 | Intelligent Refiner | .... 7 |
| 4 | Result | .... 11 |
| 5 | Discussion | .... 11 |
| Acknowledgement | .... 12 | |
| References | .... 12 | |
| End | .... 13 |
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